Friday, June 13, 2008
Very Sad News
"Tragic Loss for Journalism"
Wednesday, May 28, 2008
Where in the world...
Wish I had more interesting things to write about at this time...
Wednesday, April 30, 2008
Sham?
Or, maybe not...
Sunday, March 16, 2008
Good thing...
Dang! Tennessee is the lowest 2 seed in the NCAA tourney :(
Wednesday, February 06, 2008
A Man Named Scoobie
(photo from www.knoxnews.com)
Fallout from the February 5th primary results. Scott "Scoobie" Moore has decided to step down as Knox County Commission chair after his slaughter in the Republican primary for Knox County Clerk.
Read the comments to the article. Very entertaining...
Moore resigns as County Commission chairman
Sunday, January 06, 2008
Friday, November 23, 2007
My Bloody Valentine
Sooie!
Now, hopefully the Tigers can open up a can of whoop ass on Alabama tomorrow in the Iron Bowl (or "Arn Bowl" as they say in these here parts!)
Friday, November 16, 2007
casa degli orrori
This really hits close to home for me as we were just over in Italy with a group of university students in May. We stayed in Siena, which is about 65 miles west of Perugia.
I guess shocked best sums up my thoughts/feelings about this.
Tuesday, November 13, 2007
Saturday, November 10, 2007
Goin' Campin'
I am sure we will have a great time :)
Friday, October 12, 2007
-- Live, from high atop the Hotel Palomar --
This morning I went for my morning walk down to Georgetown -- gorgeous weather!
Even had time to get in a little bit of shopping. Today I had the pleasure of shopping at the Burberry store :)
Tomorrow we are going to see some book learnin' in action -- I mean, we are going to a few museums. My favorite is the Air and Space.
Signing off for now.....
Sunday, October 07, 2007
How well did I do?
Thursday:
SC 38 UK 23
SC 35 UK 34
Saturday:
UF 24 LSU 28
UF 17 LSU 28
UT 35 UGA 14
UT 27 UGA 24
AU 35 Vandy 7
AU 34 Vandy 17
Bama 30 Houston 24
Bama 42 Houston 21
Ole Miss 24 La Tech 0
Ole Miss 45 La Tech 14
MSU 30 UAB 13
MSU 37 UAB 21
Thursday, October 04, 2007
UK vs. the other USC
My picks for SEC games for this week:
Thursday:
SC 35 UK 34
Saturday:
UF 17 LSU 28
UT 27 UGA 24
AU 34 Vandy 17
Bama 42 Houston 21
Ole Miss 45 La Tech 14
MSU 37 UAB 21
Tuesday, July 31, 2007
Backlogged
Tuesday, June 26, 2007
From Popular Mechanics
(image from www.popularmechanics.com)
Bladerunner at 25
This article takes a look back at the brilliance of this film. OK, I know, I am a bit biased since this is one of my favorite movies of all time. The sets are amazing; the spaces look as if Frank Lloyd Wright designed them; and the videography is wonderfully futuristic yet does not look as if it is a film from the early 1980s.
Monday, June 25, 2007
Week No. 2 of the summer basketball league
The Christian Science Monitor
By Danna Harman
This article caught my attention. Get this:
Sudan's experience is hardly unique. There is more trade going on today between China and Africa than ever before. In the late 1980s, trade between the country and the continent was $12 million. Last year, according to official Chinese figures, it reached a record $55 billion. In 1991, Chinese direct investment in Africa was less than $5 million a year. In 2006 – China's official "Year of Africa" – it reached $1.25 billion, according to the Chinese Academy of Social Sciences. Sudan is the No. 1 recipient of that investment.
"The Chinese have big machines and factories and they work day and night ... and at the end of the day this means we can go shopping," says Jacob Marial, a rebel-leader-turned-bicycle repairman in Rumbek. "My wife likes green tea toothpaste."
Sunday, June 24, 2007
Pac Man Jones
Everytime there is a story about him, it always involves him being questioned about some bizarre event. Everytime he was never at the scene, just a person of interest. Now he has been charged with a crime.
It will be interesting to see how the NFL and the Titans will deal with him. I am sure it is all about the legal language of his contract.
Stay tuned.....
'Being' versus 'Having'
Secret Habits of the Super Rich: The best things in life aren't necessarily flashy objects but discreet, meaningful experiences.
Newsweek
Rana Foroohar
Sevierville/Pigeon Forge
Friday, June 22, 2007
Images from Carr Street (Chattanooga)
Thursday, June 21, 2007
Monday, June 18, 2007
Sunday--Monday
This evening we went to the first games of the Pilot Rocky Top basketball league. The games are held at Bearden High School in West Knoxville. The place was packed and rather warm but we had a great time anyway. Coach Pearl was in attendance -- he had the gaggle of sportswriters/casters hanging around him.
Here is the story from the KNS about the league:
Summer league to feature top players
Vols could be part of basketball at Bearden
By MIKE GRIFFITH, knsgriff@aol.com
May 2, 2007
A summer basketball league featuring current and former University of Tennessee men's players is coming to Bearden High School in Knoxville.
Andre Whitehead, an enterprising journalist who runs a Tennessee High School basketball Web site, put the Pilot Rocky Top League together with sponsorship from Pilot, appropriate sanctioning from the NCAA and the blessing of Vols' coach Bruce Pearl.
Whitehead, 42, said the model he used for the league is Iowa's "Prime Time League,'' which has been in existence some 20 years.
"That league has gotten so big that some of their games are shown on television and the statistics appear in the newspaper,'' Whitehead said. "I just felt this was something Knoxville needed with the emergence of basketball.''
Admission and parking for the games is free. The games will be played at Bearden High School on Monday and Wednesday nights from June 18 through July 16 at 6 p.m., 7:30 p.m. and 9 p.m.
There will be six 10-member teams made up of current collegiate players from schools' within a 100-mile radius of Knoxville, along with former local players and current and former high school players, Whitehead said.
NCAA rules dictate that there be no more than two Division I players on the same team. The league will hold a draft to disperse players to the teams, each of which has a different sponsor.
The News Sentinel is one of the businesses sponsoring a team this summer.
Whitehead said that in addition to current Vols, UT signees Cameron Tatum and Brian Williams could play. Former UT players CJ Watson and Jon Higgins are being courted to play, as is former Bearden standout Tony White Jr.
"It helps UT because some players, like Ramar (Smith) might have gone home to play in Detroit in a summer league,'' Whitehead said. "Now, he can stay here and play in a competitive league.''
Whitehead said the list of head coaches for the league includes (with former affiliation in parenthesis): Steve Adams (Tennessee Wesleyn); Rick Campbell (Lincoln Memorial); Chad Smith (South-Doyle); Andy Rines (Heritage); Pat Walden (UT) and Kevin Feltner (Carson-Newman).
Thursday, June 14, 2007
Tuesday, June 12, 2007
Monday, June 11, 2007
"Boomburbs" seek to create urban living in suburban settings
What a difference.....
I plan to post some recent photos from my trip to Italy. Currently I only have a few from the train ride from Florence to Venice. As I get more photos, I will post them.
Sunday, January 22, 2006
WOW!
Monday, January 02, 2006
The Sporting Life
Can't wait to go see a game in the near future.....
Tuesday, December 20, 2005
Shopping, and well, even more shopping - really!
Monday, December 19, 2005
Paris.....at 9.30 P.M.?!?!?!?!
Drug testing in India
Sunday, November 06, 2005
iBook G4
Still working on the thesis. Things are going well but all of my projects are due around the same time and I feel just a bit overwhelmed. Hope to make some progress on all of them later this week.
I can not believe what is going on in Paris. I was just there in June.....
Friday, October 28, 2005
I have been watching the CIA leak investigation. Pretty interesting information. Perhaps I will drink a Guinness in honor of Patrick Fitzgerald. He did conduct a professional investigation based upon the law! At least that is my opinion and I am sure there are so many out there in cyberspace who will rip me to shreds over that one, but hey, that is the chance I will take.
Looks like Mail Call will be on soon. I love that show! I have been so inspired by it that I am looking to learn how to shoot skeet.....
Friday, October 14, 2005
My New iPod
Saturday, October 01, 2005
Saturday
Nothing exciting to report at this time.....
Monday, August 22, 2005
Redefining Historic Preservation.....
Friday, August 12, 2005
Thursday, August 11, 2005
Increasing Fuel Prices.....
Monday, August 08, 2005
Hall of Fame Game
***UPDATE*** Moore is indeed with the Dolphins - check here.
Sunday, August 07, 2005
Washington Post article
Building Cells on the Web
In the last two years, a small number of cases have emerged in which jihadist cells appear to have formed among like-minded strangers who met online, according to intelligence officials and terrorism specialists. And there are many other cases in which bonds formed in the physical world have been sustained and nurtured by the Internet, according to specialists in and outside of government.
For example, Royal Canadian Mounted Police officers burst into the Ottawa home of Mohammed Momin Khawaja, a 24-year-old computer programmer, on March 29, 2004, arresting him for alleged complicity in what Canadian and British authorities described as a transatlantic plot to bomb targets in London and Canada. Khawaja, a contractor with Canada's Foreign Ministry, met his alleged British counterparts online and came to the attention of authorities only when he traveled to Britain and walked into a surveillance operation being conducted by British special police, according to two Western sources familiar with the case.
British prosecutors alleged in court that Khawaja met with his online acquaintances in an Internet cafe in London, where he showed them images of explosive devices found on the Web and told them how to detonate bombs using cell phones. The first person jailed under a strict new Canadian anti-terrorism law passed after Sept. 11, Khawaja is not scheduled to have a preliminary hearing on his case until January.
The transit attacks in London may also have an Internet connection, according to several analysts. They appear to be successful examples of "al Qaeda's assiduous effort to cultivate and train professional insurgents and urban warfare specialists via the Internet," wrote Scheuer, the former CIA analyst.
In a posting not long after the London attacks, a member of one of the al Qaeda-linked online forums asked how to take action himself. A cell of two or three people is better, replied another member in an exchange translated by the SITE Institute. Even better than that is a "virtual cell, an agreement between a group of brothers over the Internet." It is "safe," extolled the anonymous poster, and "nobody will know the identity of each other in the beginning." Once "harmony and mutual trust" are established, training conducted and videos watched, then "you can meet in reality and execute some operation in the field."
Friday, August 05, 2005
Wednesday, August 03, 2005
Isle of Palms (Charleston, SC)
This morning I did indeed leave the house by 5.45 am! Made it to work around 6.20 am. Completed both of the reports that were due by 10.00 am. Fortunately I parked close so I did not have to walk forever to my car and left around 10.05 am. Finished packing stuff when I arrived and was ready to leave by 11.15 am BUT I had to wait on David - he had to turn in grades for his second session students, so he had to go to campus. Then he had to finish packing as well. We left the house around 12.50 pm. The weather was great and traffic was okay. I am totally surprised the Volvo C70 which passed me was not pulled over. I am sure it was going between 100-105 mph.
Looking forward to spending a day at the beach :)
Tuesday, August 02, 2005
Saturday, July 30, 2005
Architecture Must Burn
***Another secret confession - I was once an architecture major as an undergraduate. I loved the design and drawing but did not like the model building part. This was before the widespread use of Microstation, Form Z and Maya.
Tuesday, July 26, 2005
Monday, July 25, 2005
WWII
Saturday, July 23, 2005
Tiger.....
Now my PC laptop is having issues, such as the DVD/CD-ROM drive. Guess I will have to use the iBook again. I like it but it is really slow - I believe it is almost 3 years old and only has a 700 MHz processor! At least I am not working on any digital video/multi-media project at the moment, so I should be able to survive.
The burning question on my mind is.....will Michael Vartan's character on Alias (Agent Vaughn) be killed off early this next season since Jennifer Garner once dated MV and is now married to Ben Affleck? Will have to wait and see.....
Debating on whether or not to have a Guinness this evening.....From the sound of this post, one would think I have already had one ;)
Tuesday, July 19, 2005
AutoBlog....
Cool cars spotted today::
'05 Mercedes-Benz SLK350
:: not thrilled by the front styling of the car (too much like the Mercedes-Benz 2005 MacLaren SLR, but love the performance of the Mac :: 0-60 in just 3.8 seconds!!!!!) but nevertheless has quite a presence on the road.
'05 Acura TL
:: ooh la la - 270 hp; sweet ride!
'05 Acura TSX
:: love the drive-by-wire technology - test drove one last year - great car!
Infiniti G35 sedan
:: 280 hp - test drove one last year as well.....
***one of the most intriguing cars I have seen around town over the past 6 months was a black Maserati Spyder GT speeding down the interstate.
Monday, July 18, 2005
CIA Covert Operative Fiasco
MSNBC/Newsweek
Instapundit
Washington Post
Washington Times
And lastly, the MTP transcript.....
Sex and the City?
I forget that Kyle MacLachlan was on the show. Must admit I really liked him in Twin Peaks. Guess I will watch the last DVD later this week.
Sunday, July 17, 2005
British Open
Saturday, July 16, 2005
This afternoon I took Eli swimming and we had a great time. For the past two hours I have been watching the third season DVD of a show to which I have recently become addicted.
Wish I were going here next week. I would love to get my private pilot's license but right now I really do not have the time.
Tuesday, July 12, 2005
The British Open
What a wonderful evening! Just returned from walking by the river on the boulevard. That is one of the things I enjoy about my neighborhood – living two blocks from the river. An interesting aspect of it is the park which is woven into the fabric of the neighborhood. Almost 1.5 miles along the river is public access. Also, a tree lined boulevard is a rarity in this town. The history dates back to the 1930s.
Blah, blah, blah.....
I have officially started the research for my thesis. Wait! I think I have been through this process in the past. Yep – two years ago BUT it was for my MFA in graphic design. During that process I realized I was in the wrong discipline as I enjoyed the research more than the design process. Whereas the first thesis focused on the built environment and suburban communities, this thesis will focus on the intelligence community, open source information (such as scientific and technical reports) and homeland security. Hopefully I will have the opportunity to interview several members of the intelligence community and go from there. So far so good with the literature search – just not as many resources as I had anticipated.
Monday, July 11, 2005
Layer Cake
"Layer Cake" has the same ingredients as a host of other recent films about the British underworld, but it still manages to seem fresh.
It's not as frenetic as "Lock, Stock and Two Smoking Barrels" or "Snatch," which is telling, since Matthew Vaughn, making his directing debut here, produced those two. It's not as menacing as "Sexy Beast" or as antisocial as "Gangster No. 1."
What most of those films have that "Layer Cake" does not is attitude. Instead, like "Sexy Beast" - though not quite reaching the same heights - "Layer Cake" has atmosphere and insight.I have seen "Sexy Beast" and menacing is an interesting way to describe the film.
Will this really make a difference?
Sunday, July 10, 2005
Meet The Press
I finally finished up The Pentagon's New Map by Thomas P.M. Barnett. I am looking forward to his next release due out this fall.
iPod Playlist.....
:: a very short list ::
Heaven or
What If - Coldplay
Bullet Proof…I Wish I Was – Radiohead
Canary In A Coalmine – The Police
I Can’t Remember – Peter Gabriel
Coffee & TV – Blur
Counting Backwards – Throwing Muses
Cuts You Up – Peter Murphy
Different Day – DJ Icey & Jen Lasher
Ecstacy – New Order
Edge of the Ocean – Ivy
Life in
Come On Closer – Jem
Getting Away With It – Electronic
From Rush Hour With Love – Republica
Glorious Day – Weezer
Something About Us – Daft Punk
Southern Sun – Paul Oakenfold
I’m Not Scared – Pet Shop Boys
Glory Box – Portishead
Ways & Means – Snow Patrol
Superfabulous – BT
Basement Jaxx- Red Alert
After – dZhihan & Kamien
Take Me Out – Franz Ferdinand
Hate to Say I Told You So – The Hives
Higher Than the Sun – Primal Scream
Do It Again – Steely Dan
I Fall For You – Fleming and John
Jetstream – New Order
Cross the Border – Icehouse
Break It Down Again – Tears for Fears
Judy Staring at the Sun – Catherine Wheel
Lips Like Sugar – Echo & the Bunnymen
Spitting Games – Snow Patrol
Friday, July 08, 2005
Zero Effect
"I can't possibly overstate the importance of good research. Everyone goes through life dropping crumbs. If you can recognize the crumbs, you can trace a path all the way back from your death certificate to the dinner and a movie that resulted in you in the first place. But research is an art, not a science, because anyone who knows what they're doing can find the crumbs, the wheres, whats, and whos. The art is in the whys: the ability to read between the crumbs, not to mix metaphors. For every event, there is a cause and effect. For every crime, a motive. And for every motive, a passion. The art of research is the ability to look at the details, and see the passion."
And now for something completely different.....
Interesting image loops here.
I am totally diggin' this free mp3 website - and it is sponsored by Mercedes-Benz.
iPOD PLAYLIST.....COMING SOON! :)
Thursday, July 07, 2005
Thursday, June 23, 2005
HIV/AIDS Vaccine Information
VAX 3(3), March 2005
IAVI Report
India changes law regarding generic medicines
India’s parliament recently passed legislation that amends the country’s 35-year-old patent law regarding the manufacture of patented medicines by generic companies, in order to allow the country to join the World Trade Organization. Indian companies will now have to pay a licensing fee to the patent holders to continue producing the currently available copied drugs, known as generics. The new law also limits the ability of generic manufacturers to copy patented drugs in the future.
Since Indian companies are a major supplier of discounted antiretroviral (ARV) drugs, many fear that the law could prevent newer and better medicines from reaching the majority of people with HIV. Companies like Cipla and Ranbaxy supply affordable ARVs to millions of people in several countries. This new policy could mean that newer generics, if available, will come with much higher prices.
“It is unclear how these drugs will be made available in the future. It could hamper access to medicines because India has played such a huge role in providing drugs throughout the developing world,” says Rachel Cohen, a US advocacy liaison at Doctors Without Borders. Cohen credits the actions of activist groups for influencing the Indian parliament from passing further limitations on the production of generic medicines.
Wednesday, June 22, 2005
A little research on the side.....
Another reason I have been contemplating exurbs must be my experience in Paris several weeks ago when we went to La Defense. This place is at the end of one of the major rail lines. As you are riding up the escalator to the plaza, the entire scene is just so surreal. Once you reach the top, you can not help but notice the extremely odd shaped arch - actually it is an office building with monumental stairs leading up to it. Concrete is everywhere - like a suburban wasteland. On the other side of La Defense is an interesting cemetary that does not look like a cemetary. At first glance it resembles some sort of maze or large scale park, which is what cemetaries were originally. It is closed in by a highway and highrises and you can look down into it. Another strange feature of the area is a pedestrian bridge that goes to nowhere. This bridge is surrounded by cement spaces that are just there. No thought behind why these spaces exist.
Honestly, surreal is the only word to describe this place.
Pimp My Ride?
Now back to the show..... The guys at West Coast Customs are extremely talented. There is an "art" to their work. The guys appear to love what they do. That is one of the secrets in life - love what you do and do it well!
Can't wait to see the new season!
Pimp My Ride
Monday, June 20, 2005
Sunday, June 19, 2005
Friday, June 17, 2005
My S_60
Just thought I would post a photo of my S_60 (courtesey of the VolvoUSA.com website) I must admit I am extremely impressed with how safety and styling come together in this car. Safety is of the utmost importance.
I am also considering buying a roof mounted bike rack. I already have one but I would need to install a hitch. One problem with that is if a Volvo dealer does the installation, then the price would be high. The other problem is if I get another type of hitch installed, it could really screw up the clearance and I really do not want that. So I guess I will ponder this situation.....
On the topic of bikes....I purchased a Specialized Hardrock last fall.
Listening:: Metric_Dead Disco
Thursday, June 16, 2005
Which Housewife Are You?
So silly! Sometimes I love trivial and shallow things - sometimes.
Shopping and well, more shopping
Watching television is the most popular activity in America. Shopping is second, yet in terms of public activity, it ranks first. Most shopping occurs in malls and big-box,suburban shopping centers. The mall replicates and replaces downtown as the physical and social focus of civic life. Malls embody urban characteristics yet they exist within a suburban context. These spaces react to the suburbs while embracing the idealized memory of Main Street. This condition blurs the notion of urban and suburban space. Thus, it creates an in-between, or liminal, condition. Liminal spaces slip between public and private and define a new, entirely different spatial experience. This thesis explores the aspect of control within this liminal condition and questions the assumptions we make when we shop in suburban malls.
The thesis begins with how one is controlled within a mall. Because the essence of a mall is control, how does this experience effect the physical environment of mall space? Malls are very calculated and scientific systems characterized by parallels to television. In this new medium, social and public activities seemingly thrive. But by controlling what one can say, do or see (no skate boarders or homeless people) the mall removes baggage common to the "real" downtown. Though shoppers feel safe and secure in this environment, they have ceded many liberties to participate in this new collective.
Shopping is interpreted as an activity where the consumer has the freedom to choose. Yet in a mall space consumers actually forgo freedoms so they may participate in the collective act of shopping. Designers fabricate physical and mental landscapes scientifically calculated to simultaneously increase sales and experience a false sense of freedom. This paradox is graphically explored in this thesis as control.
Mapping is an excellent way to understand this "control" space. Understanding the underlying structure of a mall evokes the intent of the mall designers. Maps create wonderful interfaces for humans to see and react to the environment. This project maps both the physical and the experiential aspects of the mall by recalling the literal and conceptual notions of liminal space. Within each piece, the user has the freedom to make decisions (as one does when shopping in the mall), yet one must follow the structure dictated by the piece. Especially in the digital interface, the concept of the mall is experienced in a larger context (like television). Because consumers experience a barrage of images and information while shopping inside the mall, the interactive medium solicits the user to experience similar shifts of perception of time and space. The clicking between screens and sections mimics the clicking of the remote control: a monotonous and mind numbing experience. Shopping in a mall space is akin to experiencing television in the third dimension. Here, in the liminal fog of what is real and not-real, controlled and free, is the essence of my thesis.
***COPYRIGHT 2003*** BY THE AUTHOR
Tuesday, June 14, 2005
US Open
Good luck to Fred Couples. I hope he plays well this week.
Thursday, June 09, 2005
Intelligence News....
***Thanks to InstaPundit for the heads up on this story***
Of course, I am skeptical of this story.....
Business Intelligence
STATIC ANALYSIS
HIV/AIDS Vaccine Industry
Rating the Five Forces of the HIV/AIDS Vaccine Industry (5 = strong, 1 = weak)
1. Threat of New Entrants - 3
a. Barriers to Entry
· High front-end capital investment costs in research and development (R&D).
· Difficulty in raising private funds for capital investment due to risky and expensive scientific uncertainties, especially in the area of understanding the virus (Ainsworth and Batson, 2001).
b. Experience Effects
· Five companies dominate the landscape with 93% of the market share:
Aventis Pasteur, GlaxoSmithKline (GSK), Wyeth, Merck and Chiron (Kalorama, 2004). These corporations have the infrastructure and consortia in place thus creating other cost advantages over new entrants.
· HAART (highly active anti-retroviral therapy) has been successful in decreasing HIV/AIDS mortality rates yet HIV/AIDS cases are still on the rise (Savopoulos, 2004). The opportunity for new vaccines for other facets of the disease are always in demand.
· Although the dominant companies have compounds and vaccines in several stages of the pipeline process, success is not guaranteed. The pipeline process may take from 15 – 20 years from the R&D phase until the approval phase (HIV R&D, 2001). Recently a new strain of HIV, known as HIV 2, made headlines on February 12, 2005 (MSNBC, 2005). This new strain is resistant to all HIV/AIDS vaccine and medications. The vaccines at various points in the pipeline may become obsolete. These companies will have to take previous data and create a new strategy allowing for this new strain of the virus. During this time, new companies have the opportunity to enter into the market.
· Shift from technological based acquisitions toward production based acquisitions thus allowing an opening with in the market for companies with production capabilities (Van Arnum, 2003).
c. Distribution Access
· The company securing the patent on the HIV/AIDS vaccine should not have difficulty in distribution in the
· The problem lies within getting access in other countries where the governmental regulations and cultural differences have the potential to create a barrier for entry into those foreign markets (Kalorama, 2004).
d. Government
· Changes in government regulation has created an increase in research costs from the late 1990s that have quadrupled from $80 million to $100 million dollars up to $350 million dollars per each product. This increase results from the increase in the requirements of necessary data for approval by federal standards (Navarro, 1997).
e. Product Differentiation
· Product differentiation does not pose any barrier to entry at this time. HIV/AIDS is a life threatening disease that has no proven cure at this time. Marketing is not needed for this type of vaccine.
2. Bargaining Power of Suppliers – 4
a. Concentration
· No substitute available for capital equipment (or laboratory equipment) as the technology is extremely sophisticated and specialized. In order to conduct R&D in-house, the companies must purchase this equipment from these suppliers at the price they dictate in addition to having the capability to utilize the technology.
· The top four companies have in-house R&D capabilities. Smaller companies working on HIV/AIDS vaccines do not have the capacity and must rely on smaller academic institutions and companies to provide “bioprocess development and manufacturing” (IAVI, 2005).
· High costs result from clinical trials. The average cost for a single trial begins around $30 million (Ainsworth and Batson, 2001). Patient pools must be rather large, up to 10,000 patients, as to yield proper results in the testing. Since 2000, the number of candidates in trials has doubled.
b. Organization
· Protection of intellectual property factors prominently as the top manufacturers produce the viruses, processes and chemicals in-house. Outsourcing is not an option for these top manufacturers as they are seeking patents for their product (Feliza, 2003). Higher margins and higher pricing are possible as a result.
· According to organizations such as the IAVI (International AIDS Vaccine Initiative), if a company receives funding for R&D, then they must set the price of the vaccine to be affordable in developing nations (http://www.iavi.org).
c. Government
· Shift in demands since 9|11 results in the focus to meet needs for critical vaccines to save lives (Wechsler, 2002). This shift affects FDA policy development, which affects the emphasis of federal government funding for R&D. The development of HIV/AIDS vaccine falls under this category.
· Patent suppliers and FDA approval costs have increased significantly. After the Vioxx case (recently taken off the market), the FDA recently requested more funding for the post-approval monitoring process.
3. Bargaining Power of Buyers – 1
a. Differentiation
· Guaranteed market for these vaccines creating a “seller’s market”.
b. Importance
· Buyers will purchase the vaccines based on need, not on price.
c. Importance of Quality
· Buyers will pay the price dictated by manufacturers if the vaccine is effective and of high quality.
· The focus will be on issues of quality along with manufacturer liability.
· Patent protection protects intellectual property thus allowing the manufacturer to dictate price of vaccine in most cases. So far only certain processes and chemicals have been patented, not a vaccine. Once a manufacturer obtains this patent that particular manufacturer will dictate the price. But as previously stated, manufacturer may be obligated to set the price of vaccine at an affordable price.
4. Threat of Substitute Products or Services - 4
a. Relative Price/Performance Trade-Off
· Currently the only options available for the prevention of HIV/AIDS are condom use and abstinence. Condoms are not 100% effective in the prevention of HIV/AIDS (IAVI, 2005).
· Although five companies dominate the current landscape, many more are vying for a position in the pipeline (Scrips, 2002). The first company to secure the patent for the vaccine will dominate the market.
· The arrival of the HIV 2 virus changes the dynamics of the landscape and creates uncertainty for products and services.
b. Switching Costs / Profitability
· The Bush Administration is pushing for a generic version of an HIV/AIDS vaccine to be made available for victims in underdeveloped nations such as
5. Rivalry Among Existing Competitors -3
a. Market Growth
· The market is expected to increase 9 – 11% compounding annually (Scrips 2002).
· At this time, only five companies dominate the market. The market can sustain future growth as none of the companies has produced a successful HIV/AIDS vaccine, either therapeutic or prophylactic.
Company Market Share
Aventis Pasteur 30%
GlaxoSmithKline 18%
Wyeth 17%
Merck 17%
Chiron 11%
(Chart: Kalorama 2004)
Chiron is the newest company to become a major contender in the landscape. As recently as 1999, the top four companies dominated.
b. Barriers to Exit/Switching Costs
· Low barriers due to high entry capital costs. The top five companies have diversified product lines that create low barriers.
c. Diversity
· The trend shows an influx of companies moving toward the HIV/AIDS vaccine industry. Available opportunities are abundant in this area of vaccine research. Many unknown companies have an opportunity break into the vaccine pipeline.
Conclusion: The HIV/AIDS vaccine industry is undergoing a major shift in the landscape. Although the costs for entry into the market are high and uncertainty surrounds the scientific research and understanding of the virus, the market is poised for growth. There is a great need for development of both therapeutic and prophylactic HIV/AIDS vaccines yet the pipeline process may take a decade or more. The primary forces affecting this industry include the emergence of companies vying for the creation of an effective vaccine, government and private funding, application for patents and the issue of intellectual property rights in addition to the recent discovery of the newest strain of the virus, HIV 2.